Southeast Illinois Vacations from $550

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Your Southeast Illinois Vacation

Make organizing your next big getaway a breeze with a Southeast Illinois vacation package. Whether it's the cuisine, history or something else that brings you here, our package deals will help you discover the best of it. With so many things to explore on a trip to Southeast Illinois, it can be hard to know where to begin. Kick off your travels in Effingham at Lake Sara and Effingham Performance Center — two leading attractions here. Another top city worthy of a spot on your itinerary is Metropolis. Be sure not to miss Harrah's Metropolis and Superman Statue. Whether you're traveling on a budget or in the lap of luxury, Expedia are here to help you organize your next dream Southeast Illinois vacation.

The Latest Southeast Illinois vacation packages

Price found within the past 48 hours. Click for updated prices.
Regency Inn
Harrah's Metropolis Hotel & Casino
The Respite Bed and Breakfast
La Quinta Inn & Suites by Wyndham Paducah
The Lakehouse Inn at Sledd Creek
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Southeast Illinois Hotel Deals

Country Inn & Suites by Radisson, Effingham, IL

Country Inn & Suites by Radisson, Effingham, IL

2.5 out of 5
1200 N Raney, Effingham, IL
Fully refundable
$94 nightly
The price is $104 total per night from Aug 27 to Aug 28
$104 total
Aug 27 - Aug 28
Total with taxes and fees
8.6/10 Excellent! (1,011 reviews)
"I mean over all it wasn't bad. the outlets in the room didn't work, when we left walking the doors to the outside in the hallways didn't close, but a good location close to a Walmart."

Reviewed on Aug 20, 2025

Country Inn & Suites by Radisson, Effingham, IL
La Quinta Inn & Suites by Wyndham Effingham

La Quinta Inn & Suites by Wyndham Effingham

3 out of 5
1103 Avenue Of Mid America, Effingham, IL
Fully refundableReserve now, pay when you stay
$97 nightly
The price is $109 total per night from Sep 1 to Sep 2
$109 total
Sep 1 - Sep 2
Total with taxes and fees
9.2/10 Wonderful! (1,002 reviews)
"Very clean hotel with friendly staff!"

Reviewed on Aug 22, 2025

La Quinta Inn & Suites by Wyndham Effingham
Unique Suites Hotel

Unique Suites Hotel

2.5 out of 5
920 W Lincoln Ave, Charleston, IL
Fully refundableReserve now, pay when you stay
$108 nightly
The price is $119 total per night from Sep 23 to Sep 24
$119 total
Sep 23 - Sep 24
Total with taxes and fees
8.4/10 Very Good! (672 reviews)
"The staff were very friendly."

Reviewed on Aug 21, 2025

Unique Suites Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.